Current research in oxidation-resistant carbon-carbon composites at NASA. Langley Research Center

The significant potential of carbon-carbon composites for high-temperature structural applications is well established. For hypersonic vehicle applications, desirable properties include low density, high specific strength and stiffness, low coefficients of thermal expansion, and retention of mechanical properties above 3000 F. A significant problem associated with carbon materials, however, is that they oxidize rapidly in air at temperatures above about 800 F, and therefore must be protected from oxidation. Successful development of effective methods of oxidation protection is key to the eventual utilization of carbon-carbon composites on hypersonic vehicles such as NASP. In this presentation, the basic elements of an oxidation-protection system are described. Results from oxidation-performance evaluations of state-of-the-art ACC-4 type material in simulated airframe vehicle environments (temperature, pressure, and time) conducted at NASA Langley are also presented. NASA Langley has an active research effort to improve the oxidation resistance of carbon-carbon materials for airframe structural and vehicle thermal protection applications. Conversion coating and sealant development research is highlighted

Financing an Increased State Role in Funding K-12 Education: An Analysis of Issues and Options

This report presents an analysis of replacing school property tax with alternative state revenue sources. FRC Report 11

The Pacific Center of Action of the Northern Hemisphere Annular Mode: Real or Artifact?

The leading empirical orthogonal function (EOF) of the sea level pressure (SLP) field, referred to as the Arctic Oscillation (AO) or Northern Hemisphere annular mode (NAM), consists of a dipole between the polar cap region and the surrounding zonal ring centered along 458N. Embedded within the outer ring are centers of action over the Euro-Atlantic and Pacific sectors in which SLP fluctuates in phase. That the observed SLP fluctuations at these two centers of action are virtually uncorrelated raises the question of whether the Pacific center in the annular mode could be an artifact of EOF analysis. It is argued that sea level pressure fluctuations at the Pacific and Euro-Atlantic centers of action of the AO/ NAM would be more strongly correlated were it not for the fact that SLP variability over the North Pacific is dominated by a pattern in which fluctuations over the North Atlantic and North Pacific are inversely related. Evidence of the coexistence of such a pattern, which resembles an augmented version of the Pacific–North American pattern, is presented

The Effects of a Systematic Training Program in Responding Skills on Dental Hygiene Students at Texas Woman's University

The purposes of this investigation were (1) to determine if a systematic training program in communication skills could be used to improve written response levels of dental hygiene students, and (2) to determine if a systematic training program in communication skills could yield improved dental hygiene student-patient rapport. The experiment involved two groups of dental hygiene students that had previously been randomly selected and consisted of twelve junior and twelve senior students in each group. The entire population of dental hygiene students at Texas Woman's University participated in the study. Analysis of the data provided statistically significant findings on seven of the eight hypotheses. Those subjects in the systematic training program were able to demonstrate increased ability to write responses and, in addition, had higher patient rapport scores. The results were also statistically significant two weeks following the training period. It was, therefore, concluded that the systematic training program in communication skills was an effective teaching device for improving dental hygiene responses. The systematic training program also seemed to be an effective strategy for improving dental hygiene student-patient rapport formation

Emphysema : the challenge of the remodelled lung

Emphysema is recognized as the component of chronic obstructive airways disease that is responsible for airways obstruction. Different patterns of emphysema are, however, recognized, suggesting possible different pathogenetic processes within the lung. This, coupled with the associated idea of susceptibility factors to the development of emphysema, has led to studies of genes that may be involved in the defence of the lung from proteolytic and oxidative damage. These studies have been driven by the goal of finding a treatment for emphysema, but appear to have lost sight of the fundamental remodelling of the lung that has occurred in patients with emphysema and the fact that it is not a single morphological entity.peer-reviewe

Response of a rare endemic, Penstemon clutei, to burning and reduced belowground competition

Penstemon clutei, a rare perennial beard tongue endemic to the ponderosa pine forest of the Sunset Crater volcanic field of northern Arizona, presents an opportunity to test the hypothesis that restoration of historic ecosystem conditions may enhance the sustainability of a rare species. We tested prescribed burning and root trenching treatments as proxies for the surface fires and reduced tree densities characteristic of historic ponderosa pine ecosystems in a study area at OLeary Peak, part of the Sunset Crater volcanic field (Coconino National Forest, AZ). Prescribed burning killed many mature P. clutei plants and negatively affected density for at least 3 years post-burn. In contrast, trenching to cut root competition of overstory trees led to a 1200 percent increase in P. clutei plants. Precipitation influenced the response. Seed germination experiments showed that P. clutei does not have innate dormancy. Germination rates in the lab ranged from 5 to 70 percent under a range of environmental and fire-related conditions (i.e., cold stratification, light, exposure to ash, NH4), but these factors were not statistically significant. Tested seedling establishment rates in situ were very low (0.4(percent)). These experiments suggest that the observed P. clutei population increase following severe wildfires (1973 Burnt fire, 1996 Hochderffer fire) may have been due primarily to the removal of tree competition rather than to direct fire effects. Further experimentation is suggested to develop ecological information for thoughtful integration of ecosystem restoration with the habitat needs of rare plants

Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility.

Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2). We recently reported that MMP-2 levels were increased in the border zone after a MI and that treatment with doxycycline for two weeks after MI was associated with normalization of MMP-2 levels and improvement in ex-vivo contractile protein developed force in the myocardial border zone. The purpose of the current study was to determine if there is a sustained effect of short term treatment with doxycycline (Dox) on border zone function in a large animal model of antero-apical myocardial infarction (MI). Antero-apical MI was created in 14 sheep. Seven sheep received doxycycline 0.8 mg/kg/hr IV for two weeks. Cardiac MRI was performed two weeks before, and then two and six weeks after MI. Two sheep died prior to MRI at six weeks from surgical/anesthesia-related causes. The remaining 12 sheep completed the protocol. Doxycycline induced a sustained reduction in intracellular MMP-2 by Western blot (3649±643 MI+Dox vs 9236±114 MI relative intensity; p = 0.0009), an improvement in ex-vivo contractility (65.3±2.0 MI+Dox vs 39.7±0.8 MI mN/mm2; p<0.0001) and an increase in ventricular wall thickness at end-systole 1.0 cm from the infarct edge (12.4±0.6 MI+Dox vs 10.0±0.5 MI mm; p = 0.0095). Administration of doxycycline for a limited two week period is associated with a sustained improvement in ex-vivo contractility and an increase in wall thickness at end-systole in the border zone six weeks after MI. These findings were associated with a reduction in intracellular MMP-2 activity

Telomeres Cluster De Novo before the Initiation of Synapsis: A Three-dimensional Spatial Analysis of Telomere Positions before and during Meiotic Prophase

We have analyzed the progressive changes in the spatial distribution of telomeres during meiosis using three-dimensional, high resolution fluorescence microscopy. Fixed meiotic cells of maize (Zea mays L.) were subjected to in situ hybridization under conditions that preserved chromosome structure, allowing identification of stage-dependent changes in telomere arrangements. We found that nuclei at the last somatic prophase before meiosis exhibit a nonrandom, polarized chromosome organization resulting in a loose grouping of telomeres. Quantitative measurements on the spatial arrangements of telomeres revealed that, as cells passed through premeiotic interphase and into leptotene, there was an increase in the frequency of large telomere-to-telomere distances and a decrease in the bias toward peripheral localization of telomeres. By leptotene, there was no obvious evidence of telomere grouping, and the large, singular nucleolus was internally located, nearly concentric with the nucleus. At the end of leptotene, telomeres clustered de novo at the nuclear periphery, coincident with a displacement of the nucleolus to one side. The telomere cluster persisted throughout zygotene and into early pachytene. The nucleolus was adjacent to the cluster at zygotene. At the pachytene stage, telomeres rearranged again by dispersing throughout the nuclear periphery. The stagedependent changes in telomere arrangements are suggestive of specific, active telomere-associated motility processes with meiotic functions. Thus, the formation of the cluster itself is an early event in the nuclear reorganizations associated with meiosis and may reflect a control point in the initiation of synapsis or crossing over

A demonstration project to test ecological restoration of a pinyon-juniper ecosystem

To test an approach for restoring historical stand densities and increasing plant species diversity of a pinyon-juniper ecosystem, we implemented a demonstration project at two sites (CR and GP) on the Grand Canyon-Parashant National Monument in northern Arizona. Historical records indicated that livestock grazing was intensive on the sites beginning in the late 1800s and continuing through the mid 1900s. Repeat aerial photographs (1940 and 1992) indicated recent increases in stand density and encroachment of trees into formerly open areas. Age distributions indicated that the majority of pinyon trees at both sites were less than 100 years of age and juniper establishment appeared to peak in the late 1800s to early 1900s, although some junipers had establishment dates as early as 1700-1725. Pretreatment understory communities were sparse (50% pinyon mortality, which was positively related to tree size and age. The demonstration treatment consisted of thinning small trees (< 25 cm diameter at root collar (DRC)), lopping and scattering thinned trees, and seeding native understory species. Thinning and mortality reduced overstory density from 638 and 832 trees per hectare pretreatment (258 and 337 trees per acre) to 280 and 251 trees per hectare (113 and 102 per acre) posttreatment at CR and GP, respectively. Posttreatment densities were similar to those suggested for the late 1800s by dendrochronological stand reconstructions. Thinning small diameter pinyon increased residual quadratic mean diameter (QMD) at CR and the relative importance of juniper at both sites. Live canopy fuels were reduced by treatment at CR and by thinning plus beetle-related mortality at GP. Although thinning slash was lopped and scattered, woody surface fuels were not significantly different between treated and control units at either site, perhaps due to the small size of thinned trees and the large interspace areas into which slash was scattered. Treatment had no immediate effects on herbaceous cover or species richness, both of which may take more time to develop. Further monitoring will help to clearly evaluate the effectiveness of this treatment for satisfying restoration and conservation goals